Background: Periodontal disease and dental caries are two common dental and oral diseases in Indonesia. One of the bacteria that causes periodontal disease is the bacterium Porphyromonas gingivalis and the cause of dental caries is the bacterium Streptococcus mutans. Subgingival plaque often contains anaerobic gram-negative bacteria such as Porphyromonas gingivalis. Streptococcus mutans bacteri…